SR 13800

• Supplier: Tocris Bioscience
• Catalog: 2969
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 227321-12-2
• Chemical Name: 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
• Formula: C25H29N3O2S
• Molecular Weight: 435.58
• Purity: >98 %
• Description: Potent MCT1 inhibitor (IC 50 = 0.5 nM); blocks proliferation of Raji lymphoma cells in vitro . Also inhibits lactate uptake in breast cancer cells in vitro .

Product References

In vitro and in vivo biological activities of SR140333, a novel potent - In vitro and in vivo biological activities of SR140333, a novel potent

Emonds-Alt X, Doutremepuich JD, Heaulme M, Neliat G, Santucci V, Steinberg R, Vilain P, Bichon D, Ducoux JP, Proietto V, et al.. Eur J Pharmacol. 1993 Dec 21;250(3):403-13.

Inhibition by SR 140333 of NK1 tachykinin receptor-evoked, nitric oxide-dependent - Inhibition by SR 140333 of NK1 tachykinin receptor-evoked, nitric oxide-dependent

Hall JM, Brain SD. Br J Pharmacol. 1994 Oct;113(2):522-6.

SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 - SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1

Oury-Donat F, Lefevre IA, Thurneyssen O, Gauthier T, Bordey A, Feltz P, Emonds-Alt X, Le Fur G, Soubrie P. J Neurochem. 1994 Apr;62(4):1399-407.

Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase - Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase

Nieuwmeyer F, Ye J, Huizinga JD. J Pharmacol Exp Ther. 2006 Apr;317(1):439-45. Epub 2005 Dec 5.