SR 141716A

• Supplier: Tocris Bioscience
• Catalog: 4012
• Prices: $99.00, $419.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 158681-13-1
• Chemical Name: N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamidehydrochloride
• Formula: C22H21Cl3N4O.HCl
• Molecular Weight: 500.25
• Purity: >99 %
• Description: Potent and selective cannabinoid CB 1 receptor antagonist (K i = 1.98 nM). Also acts as an inverse agonist reversing adenylyl cyclase inhibition by WIN 55,212-2 (Cat.No. 1038) (IC 50 = 48 nM). Displays no activity at CB 2 receptors. Reduces food intake and body weight in orally dosed non-obese Wistar rats.

Product References

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. - SR141716A, a potent and selective antagonist of the brain cannabinoid receptor.

Rinaldi-Carmona M, Barth F, Heaulme M, Shire D, Calandra B, Congy C, Martinez S, Maruani J, Neliat G, Caput D, et al.. FEBS Lett. 1994 Aug 22;350(2-3):240-4.

Biochemical and pharmacological characterisation of SR141716A, the first potent - Biochemical and pharmacological characterisation of SR141716A, the first potent

Rinaldi-Carmona M, Barth F, Heaulme M, Alonso R, Shire D, Congy C, Soubrie P, Breliere JC, Le Fur G. Life Sci. 1995;56(23-24):1941-7.

Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. - Appetite suppression and weight loss after the cannabinoid antagonist SR 141716.

Colombo G, Agabio R, Diaz G, Lobina C, Reali R, Gessa GL. Life Sci. 1998;63(8):PL113-7.

Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, - Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile,

Janiak P, Poirier B, Bidouard JP, Cadrouvele C, Pierre F, Gouraud L, Barbosa I, Dedio J, Maffrand JP, Le Fur G, O'Connor S, Herbert JM. Kidney Int. 2007 Dec;72(11):1345-57. Epub 2007 Sep 19.