SR 142948

• Supplier: Tocris Bioscience
• Catalog: 0923
• Prices: $125.00, $269.00
• Sizes: 1 mg, 10 mg
• Function Type: Antagonist
• Cas Number: 184162-64-9
• Chemical Name: 2-[[[5-(2,6-Dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)propyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylicacid
• Formula: C39H51N5O6
• Molecular Weight: 685.86
• Purity: >97 %
• Description: Potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC 50 = 0.32 - 3.96 nM; K i < 10 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo .

Product References

Biochemical and pharmacological activities of SR 142948A, a new potent - Biochemical and pharmacological activities of SR 142948A, a new potent

Gully D, Labeeuw B, Boigegrain R, Oury-Donat F, Bachy A, Poncelet M, Steinberg R, Suaud-Chagny MF, Santucci V, Vita N, Pecceu F, Labbe-Jullie C, Kitabgi P, Soubrie P, Le Fur G, Maffrand JP. J Pharmacol Exp Ther. 1997 Feb;280(2):802-12.

X-ray structural characterization of SR 142948, a novel potent synthetic - X-ray structural characterization of SR 142948, a novel potent synthetic

Quere L, Longfils G, Boigegrain R, Labeeuw B, Gully D, Durant F. Bioorg Med Chem Lett. 1998 Mar 17;8(6):653-8.

Effects of the selective neurotensin antagonist SR 142948A on - Effects of the selective neurotensin antagonist SR 142948A on

Marie-Claire C, Palminteri S, Romualdi P, Noble F. Neuropharmacology. 2008 Jun;54(7):1107-11.