SR 1664

• Supplier: Tocris Bioscience
• Catalog: 4424
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 1338259-05-4
• Chemical Name: 4'-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-[1,1'-biphenyl]-2-carboxylicacid
• Formula: C33H29N3O5
• Molecular Weight: 547.6
• Purity: >97 %
• Description: Antidiabetic agent; binds to PPAR γ and potently inhibits Cdk5-mediated PPAR γ phosphorylation (IC 50 = 80 nM; K i = 28.67 nM) without exhibiting PPAR γ agonist activity. Does not inhibit Cdk5-dependent phosphorylation of Rb. Reduces fasting insulin levels and improves insulin sensitivity in a mouse model of diabetes.

Product References

Antidiabetic actions of a non-agonist PPARgamma ligand blocking Cdk5-mediated - Antidiabetic actions of a non-agonist PPARgamma ligand blocking Cdk5-mediated

Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schurer SC, Vidovic D, Shulman GI, Spiegelman BM, Griffin PR. Nature. 2011 Sep 4;477(7365):477-81.

A second chance for a PPARgamma targeted therapy? - A second chance for a PPARgamma targeted therapy?

Norris AW, Sigmund CD. Circ Res. 2012 Jan 6;110(1):8-11.