SR 2640 hydrochloride

Name SR 2640 hydrochloride
Supplier Tocris Bioscience
Catalog 4869
Prices $139.00, $585.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 146662-42-2
Chemical Name 2-[[3-(2-Quinolinylmethoxy)phenyl]amino]benzoicacidhydrochloride
Formula C23H18N2O3.HCl
Molecular Weight 406.87
Purity >99 %
Description Potent and selective competitive leukotriene D 4 and E 4 receptor antagonist. Inhibits LTD 4 - but not histamine-induced guinea pig ileum and trachea contraction (pA 2 = 8.7). Also inhibits LTD 4 -attenuation of human PMN chemotaxis. Orally active in vivo .
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Product References

A novel leukotriene D4/E4 antagonist, SR2640 - A novel leukotriene D4/E4 antagonist, SR2640

Ahnfelt-Ronne I, Kirstein D, Kaergaard-Nielsen C. Eur J Pharmacol. 1988 Oct 11;155(1-2):117-28.

Inhibition by the LTD4 antagonist, SR2640, of effects of LTD4 on canine - Inhibition by the LTD4 antagonist, SR2640, of effects of LTD4 on canine

Thomsen MK, Ahnfelt-Ronne I. Biochem Pharmacol. 1989 Jul 15;38(14):2291-5.

LTD4 increases cytosolic free calcium and inositol phosphates in human - LTD4 increases cytosolic free calcium and inositol phosphates in human

Bouchelouche PN, Ahnfelt-Ronne I, Thomsen MK. Agents Actions. 1990 Mar;29(3-4):299-307.