SR 27897

• Supplier: Tocris Bioscience
• Catalog: 1804
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 136381-85-6
• Chemical Name: 2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-aceticacid
• Formula: C20H14ClN3O3S
• Molecular Weight: 411.86
• Purity: >99 %
• Description: Potent, non-peptide CCK 1 receptor antagonist that displays > 33-fold selectivity over CCK 2 receptors (EC 50 values are 6 and 200 nM respectively). Causes an increase in plasma leptin levels and increases food intake in rats in vivo .

Product References

Contrasting roles of leu(356) in the human CCK(1) receptor for antagonist SR - Contrasting roles of leu(356) in the human CCK(1) receptor for antagonist SR

Gouldson P, Legoux P, Carillon C, Delpech B, Le Fur G, Ferrara P, Shire D. Eur J Pharmacol. 1999 Nov 3;383(3):339-46.

Regulation of leptin distribution between plasma and cerebrospinal fluid by - Regulation of leptin distribution between plasma and cerebrospinal fluid by

Cano V, Ezquerra L, Ramos MP, Ruiz-Gayo M. Br J Pharmacol. 2003 Oct;140(4):647-52.