SR 33805 oxalate

• Supplier: Tocris Bioscience
• Catalog: 2190
• Prices: $225.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 121346-33-6
• Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[4-[[1-methyl-3-(1-methylethyl)-1H-indol-2-yl]sulfonyl]phenoxy]propyl]benzeneethanamine
• Formula: C32H40N2O5S.C2H2O4
• Molecular Weight: 654.77
• Purity: >99 %
• Description: Potent Ca 2+ channel antagonist; binds allosterically to the a 1 -subunit of L-type Ca 2+ channels (K d = 20 pM), at a site distinct from other types of blocker. Shows some selectivity for vascular smooth muscle, inducing vasorelaxation without producing inotropic or chronotropic effects. Inhibits PDGF-stimulated smooth muscle cell proliferation.

Product References

In vitro characterization of a novel Ca2+ entry blocker: SR 33805. - In vitro characterization of a novel Ca2+ entry blocker: SR 33805.

Chatelain P, Clinet M, Polster P, Christophe B, Manning AS. Eur J Pharmacol. 1993 Aug 15;246(3):181-93.

Effects of a new class of calcium antagonists, SR33557 (fantofarone) and SR33805, - Effects of a new class of calcium antagonists, SR33557 (fantofarone) and SR33805,

Romey G, Lazdunski M. J Pharmacol Exp Ther. 1994 Dec;271(3):1348-52.

Smooth muscle cell cycle and proliferation. Relationship between calcium influx - Smooth muscle cell cycle and proliferation. Relationship between calcium influx

Magnier-Gaubil C, Herbert JM, Quarck R, Papp B, Corvazier E, Wuytack F, Levy-Toledano S, Enouf J. J Biol Chem. 1996 Nov 1;271(44):27788-94.