SR 48692

• Supplier: Tocris Bioscience
• Catalog: 3667
• Prices: $255.00, $1,045.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 146362-70-1
• Chemical Name: 2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylicacid
• Formula: C32H31ClN4O5
• Molecular Weight: 587.07
• Purity: >98 %
• Description: Neurotensin antagonist; selective for NTS 1 over NTS 2 (apparent affinity, K e , is 36 nM for NTS 1 ). Competitively inhibits binding of [ 125 I]-neurotensin to HT29 and N1E115 cell membranes (IC 50 values are 15.3 and 20.4 nM respectively). Orally bioavailable.

Product References

Biochemical and pharmacological profile of a potent and selective nonpeptide - Biochemical and pharmacological profile of a potent and selective nonpeptide

Gully D, Canton M, Boigegrain R, Jeanjean F, Molimard JC, Poncelet M, Gueudet C, Heaulme M, Leyris R, Brouard A, et al.. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):65-9.

Characterization of the effect of SR48692 on inositol monophosphate, cyclic GMP - Characterization of the effect of SR48692 on inositol monophosphate, cyclic GMP

Oury-Donat F, Thurneyssen O, Gonalons N, Forgez P, Gully D, Le Fur G, Soubrie P. Br J Pharmacol. 1995 Sep;116(2):1899-905.

The identification of nonpeptide neurotensin receptor partial agonists from the - The identification of nonpeptide neurotensin receptor partial agonists from the

Thomas JB, Navarro H, Warner KR, Gilmour B. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1438-41.