SR 49059

• Supplier: Tocris Bioscience
• Catalog: 3721
• Prices: $319.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 150375-75-0
• Chemical Name: (2S)-1-[[(2R,3S)-5-Chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-hydroxy-1H-indol-2-yl]carbonyl]-2-pyrrolidinecarboxamide
• Formula: C28H27Cl2N3O7S
• Molecular Weight: 620.5
• Purity: >99 %
• Description: Potent and selective non-peptide vasopressin V 1A receptor antagonist; devoid of agonist activity. Displays high affinity and efficacy at both rat (K i = 1.6 nM) and human (K i = 1.1 - 6.3 nM) V 1A receptors. Potently antagonizes arginine vasopressin-induced effects in vitro (IC 50 = 3.7 nM for inhibition of human platelet aggregation) and is orally active in vivo .

Product References

Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide - Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide

Serradeil-Le Gal C, Wagnon J, Garcia C, Lacour C, Guiraudou P, Christophe B, Villanova G, Nisato D, Maffrand JP, Le Fur G, et al.. J Clin Invest. 1993 Jul;92(1):224-31.

Identification of the binding sites of the SR49059 nonpeptide antagonist into the - Identification of the binding sites of the SR49059 nonpeptide antagonist into the

Tahtaoui C, Balestre MN, Klotz P, Rognan D, Barberis C, Mouillac B, Hibert M. J Biol Chem. 2003 Oct 10;278(41):40010-9. Epub 2003 Jul 17.