SRPIN340

• Supplier: Tocris Bioscience
• Catalog: 3642
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 218156-96-8
• Chemical Name: N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide
• Formula: C18H18F3N3O
• Molecular Weight: 349.35
• Purity: >98 %
• Description: Selective serine arginine protein kinase (SRPK) 1 inhibitor (K i = 0.89 μ M). Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other classes of SR kinases. Down-regulates expression of VEGF 165 but does not affect VEGF 165b expression.

Product References

Utilization of host SR protein kinases and RNA-splicing machinery during viral - Utilization of host SR protein kinases and RNA-splicing machinery during viral

Fukuhara T, Hosoya T, Shimizu S, Sumi K, Oshiro T, Yoshinaka Y, Suzuki M, Yamamoto N, Herzenberg LA, Herzenberg LA, Hagiwara M. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11329-33. Epub 2006 Jul 13.

SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for - SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for

Oltean S, Gammons M, Hulse R, Hamdollah-Zadeh M, Mavrou A, Donaldson L, Salmon AH, Harper SJ, Ladomery MR, Bates DO. Biochem Soc Trans. 2012 Aug;40(4):831-5.

SRPK1 inhibition modulates VEGF splicing to reduce pathological - SRPK1 inhibition modulates VEGF splicing to reduce pathological

Gammons MV, Dick AD, Harper SJ, Bates DO. Invest Ophthalmol Vis Sci. 2013 Aug 27;54(8):5797-806. doi: