ST 1936 oxalate

• Supplier: Tocris Bioscience
• Catalog: 2506
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 1210-81-7
• Chemical Name: 5-Chloro-3-[2-(dimethylamino)ethyl]-2-methylindoleoxalate
• Formula: C13H17ClN2.C2H2O4
• Molecular Weight: 326.78
• Purity: >98 %
• Description: High affinity, selective agonist of 5-HT 6 receptors (K i values are 13, 168, and 245 nM for human 5-HT 6 , 5-HT 7 and 5-HT 2B receptors respectively). Displays moderate affinity for human α 2 adrenergic receptors (K i = 300 nM). Shown to increase Ca 2+ concentration and phosphorylation of Fyn kinase, and regulate the activation of ERK1/2 in cloned cells.

Product References

ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of - ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of

Riccioni T, Bordi F, Minetti P, Spadoni G, Yun HM, Im BH, Tarzia G, Rhim H, Borsini F. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14.

A microdialysis study of ST1936, a novel 5-HT6 receptor agonist. - A microdialysis study of ST1936, a novel 5-HT6 receptor agonist.

Valentini V, Frau R, Bordi F, Borsini F, Di Chiara G. Neuropharmacology. 2011 Mar;60(4):602-8.