Staurosporine

• Supplier: Tocris Bioscience
• Catalog: 3741
• Prices: $139.00
• Sizes: 100 µg
• Function Type: Inhibitor
• Cas Number: 62996-74-1
• Chemical Name: [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• Formula: C28H26N4O3
• Molecular Weight: 466.54
• Purity: >98 %
• Description: Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC 50 = 3 nM), protein kinase A (IC 50 = 7 nM), p 60v-src tyrosine protein kinase (IC 50 = 6 nM) and CaM kinase II (IC 50 = 20 nM).

Product References

Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase. - Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.

Tamaoki T, Nomoto H, Takahashi I, Kato Y, Morimoto M, Tomita F. Biochem Biophys Res Commun. 1986 Mar 13;135(2):397-402.

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein - Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein

Ruegg UT, Burgess GM. Trends Pharmacol Sci. 1989 Jun;10(6):218-20.

Staurosporine: an effective inhibitor for Ca2+/calmodulin-dependent protein - Staurosporine: an effective inhibitor for Ca2+/calmodulin-dependent protein

Yanagihara N, Tachikawa E, Izumi F, Yasugawa S, Yamamoto H, Miyamoto E. J Neurochem. 1991 Jan;56(1):294-8.