| Name | STF 083010 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2204 |
| Prices | $175.00, $709.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 307543-71-1 |
| Chemical Name | N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide |
| Formula | C15H11NO3S2 |
| Molecular Weight | 317.38 |
| Purity | >98 % |
| Description | Inhibitor of IRE1 α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138 + multiple myeloma (MM) cells in vitro ; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo . Does not alter IRE1 α kinase activity. |
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Papandreou I, Denko NC, Olson M, Van Melckebeke H, Lust S, Tam A, Solow-Cordero DE, Bouley DM, Offner F, Niwa M, Koong AC. Blood. 2011 Jan 27;117(4):1311-4.
Kraskiewicz H, FitzGerald U. Trends Pharmacol Sci. 2012 Feb;33(2):53-63.