SU 11274

• Supplier: Tocris Bioscience
• Catalog: 4749
• Prices: $249.00, $1,025.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 658084-23-2
• Chemical Name: (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide
• Formula: C28H30ClN5O4S
• Molecular Weight: 568.09
• Purity: >97 %
• Description: Selective inhibitor of MET tyrosine kinase activity (IC 50 = 0.01 μ M in vitro ). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo .

Product References

A novel small molecule met inhibitor induces apoptosis in cells transformed by - A novel small molecule met inhibitor induces apoptosis in cells transformed by

Sattler M, Pride YB, Ma P, Gramlich JL, Chu SC, Quinnan LA, Shirazian S, Liang C, Podar K, Christensen JG, Salgia R. Cancer Res. 2003 Sep 1;63(17):5462-9.

Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter - Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter

Wang X, Le P, Liang C, Chan J, Kiewlich D, Miller T, Harris D, Sun L, Rice A, Vasile S, Blake RA, Howlett AR, Patel N, McMahon G, Lipson KE. Mol Cancer Ther. 2003 Nov;2(11):1085-92.

The MET receptor tyrosine kinase is a potential novel therapeutic target for head - The MET receptor tyrosine kinase is a potential novel therapeutic target for head

Seiwert TY, Jagadeeswaran R, Faoro L, Janamanchi V, Nallasura V, El Dinali M, Yala S, Kanteti R, Cohen EE, Lingen MW, Martin L, Krishnaswamy S, Klein-Szanto A, Christensen JG, Vokes EE, Salgia R. Cancer Res. 2009 Apr 1;69(7):3021-31.