SU 4312

• Supplier: Tocris Bioscience
• Catalog: 3607
• Prices: $249.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 5812-07-7
• Chemical Name: 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one
• Formula: C17H16N2O
• Molecular Weight: 264.33
• Description: Potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC 50 values are 0.8 and 19.4 μ M respectively). Selective over EGFR and c-Src tyrosine kinases.

Product References

Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel - Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel

Sun L, Tran N, Tang F, App H, Hirth P, McMahon G, Tang C. J Med Chem. 1998 Jul 2;41(14):2588-603.

Tyrosine kinase activity of purified recombinant cytoplasmic domain of - Tyrosine kinase activity of purified recombinant cytoplasmic domain of

Zaman GJ, Vink PM, van den Doelen AA, Veeneman GH, Theunissen HJ. Biochem Pharmacol. 1999 Jan 1;57(1):57-64.

Vascular endothelial growth factor receptor KDR tyrosine kinase activity is - Vascular endothelial growth factor receptor KDR tyrosine kinase activity is

Kendall RL, Rutledge RZ, Mao X, Tebben AJ, Hungate RW, Thomas KA. J Biol Chem. 1999 Mar 5;274(10):6453-60.