SU 5402

• Supplier: Tocris Bioscience
• Catalog: 1459
• Prices: $225.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 215543-92-3
• Chemical Name: 2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoicacid
• Formula: C17H16N2O3
• Molecular Weight: 296.32
• Purity: >95 %
• Description: Potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC 50 values are 0.02, 0.03, 0.51 and > 100 μ M at VEGFR2, FGFR1, PDGFR β and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo . Also attenuates integrin β 4-induced differentiation of neural stem cells.

Product References

Design, synthesis, and evaluations of substituted 3-[(3- or - Design, synthesis, and evaluations of substituted 3-[(3- or

Sun L, Tran N, Liang C, Tang F, Rice A, Schreck R, Waltz K, Shawver LK, McMahon G, Tang C. J Med Chem. 1999 Dec 16;42(25):5120-30.

Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic - Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic

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FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward - FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward

Tanaka Y, Okada Y, Hirokawa N. Nature. 2005 May 12;435(7039):172-7.

Neural stem cell differentiation is mediated by integrin beta4 in vitro. - Neural stem cell differentiation is mediated by integrin beta4 in vitro.

Su L, Lv X, Xu J, Yin D, Zhang H, Li Y, Zhao J, Zhang S, Miao J. Int J Biochem Cell Biol. 2009 Apr;41(4):916-24. doi: