SU 5416

• Supplier: Tocris Bioscience
• Catalog: 3300
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 204005-46-9
• Chemical Name: 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
• Formula: C15H14N2O
• Molecular Weight: 238.28
• Purity: >99 %
• Description: Inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. Displays no activity against EGFR, HER2, IGF1R and PDGFR. Inhibits tumor vascularization and growth of multiple tumor types.

Product References

SU5416 is a potent and selective inhibitor of the vascular endothelial growth - SU5416 is a potent and selective inhibitor of the vascular endothelial growth

Fong TA, Shawver LK, Sun L, Tang C, App H, Powell TJ, Kim YH, Schreck R, Wang X, Risau W, Ullrich A, Hirth KP, McMahon G. Cancer Res. 1999 Jan 1;59(1):99-106.

The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF - The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF

Smolich BD, Yuen HA, West KA, Giles FJ, Albitar M, Cherrington JM. Blood. 2001 Mar 1;97(5):1413-21.

Inhibition of RET tyrosine kinase by SU5416. - Inhibition of RET tyrosine kinase by SU5416.

Mologni L, Sala E, Cazzaniga S, Rostagno R, Kuoni T, Puttini M, Bain J, Cleris L, Redaelli S, Riva B, Formelli F, Scapozza L, Gambacorti-Passerini C. J Mol Endocrinol. 2006 Oct;37(2):199-212.