SU 6668

• Supplier: Tocris Bioscience
• Catalog: 3037
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 252916-29-3
• Chemical Name: 5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid
• Formula: C18H18N2O3
• Molecular Weight: 310.35
• Purity: >99 %
• Description: ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC 50 values are 0.06, 2.43, 3.04 and > 100 μ M at PDGFR β , VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC 50 values are 0.41, 9.3 and 16.5 μ M for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo . Exhibits antiangiogenic, anti-inflammatory, antimetastatic and proapoptotic activity and is orally active.

Product References

Design, synthesis, and evaluations of substituted 3-[(3- or - Design, synthesis, and evaluations of substituted 3-[(3- or

Sun L, Tran N, Liang C, Tang F, Rice A, Schreck R, Waltz K, Shawver LK, McMahon G, Tang C. J Med Chem. 1999 Dec 16;42(25):5120-30.

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of - SU6668 is a potent antiangiogenic and antitumor agent that induces regression of

Laird AD, Vajkoczy P, Shawver LK, Thurnher A, Liang C, Mohammadi M, Schlessinger J, Ullrich A, Hubbard SR, Blake RA, Fong TA, Strawn LM, Sun L, Tang C, Hawtin R, Tang F, Shenoy N, Hirth KP, McMahon G, Cherrington. Cancer Res. 2000 Aug 1;60(15):4152-60.

TSU68 prevents liver metastasis of colon cancer xenografts by modulating the - TSU68 prevents liver metastasis of colon cancer xenografts by modulating the

Yamamoto M, Kikuchi H, Ohta M, Kawabata T, Hiramatsu Y, Kondo K, Baba M, Kamiya K, Tanaka T, Kitagawa M, Konno H. Cancer Res. 2008 Dec 1;68(23):9754-62.