[D-Arg 1 ,D-Phe 5 ,D-Trp 7,9 ,Leu 11 ]-Substance P

Name [D-Arg 1 ,D-Phe 5 ,D-Trp 7,9 ,Leu 11 ]-Substance P
Supplier Tocris Bioscience
Catalog 1156
Prices $139.00
Sizes 1 mg
Function Type Antagonist
Cas Number 96736-12-8
Formula C79H109N19O12
Molecular Weight 1516.85
Description Broad spectrum neuropeptide antagonist/inverse agonist. Potent full inverse agonist for the ghrelin receptor (EC 50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth in vitro .
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Product References

[D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P induces apoptosis in lung cancer - [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P induces apoptosis in lung cancer

Reeve JG, Bleehen NM. Biochem Biophys Res Commun. 1994 Mar 30;199(3):1313-9.

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P acts as a biased agonist toward - [D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P acts as a biased agonist toward

Jarpe MB, Knall C, Mitchell FM, Buhl AM, Duzic E, Johnson GL. J Biol Chem. 1998 Jan 30;273(5):3097-104.

High constitutive signaling of the ghrelin receptor--identification of a potent - High constitutive signaling of the ghrelin receptor--identification of a potent

Holst B, Cygankiewicz A, Jensen TH, Ankersen M, Schwartz TW. Mol Endocrinol. 2003 Nov;17(11):2201-10. Epub 2003 Aug 7.