TAK 715

• Supplier: Tocris Bioscience
• Catalog: 5209
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 303162-79-0
• Chemical Name: N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide
• Formula: C24H21N3OS
• Molecular Weight: 399.51
• Purity: >99 %
• Description: Inhibitor of p38 MAPK (IC 50 = 7.1 nM for p38 MAPK α ). Also inhibits Wnt-3a-stimulated β -catenin signaling. Inhibits 22 kinases by more than 80%, including CK1 δ / ε . Anti-inflammatory and anti-rheumatoid arthritis agent. Orally bioavailable.

Product References

Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of - Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of

Miwatashi S, Arikawa Y, Kotani E, Miyamoto M, Naruo K, Kimura H, Tanaka T, Asahi S, Ohkawa S. J Med Chem. 2005 Sep 22;48(19):5966-79.

Inhibition of Wnt/beta-catenin signaling by p38 MAP kinase inhibitors is - Inhibition of Wnt/beta-catenin signaling by p38 MAP kinase inhibitors is

Verkaar F, van der Doelen AA, Smits JF, Blankesteijn WM, Zaman GJ. Chem Biol. 2011 Apr 22;18(4):485-94.