Talampanel

Name Talampanel
Supplier Tocris Bioscience
Catalog 5403
Prices $195.00
Sizes 10 mg
Function Type Antagonist
Cas Number 161832-65-1
Chemical Name (8R)-7-Acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
Formula C19H19N3O3
Molecular Weight 337.37
Purity >98 %
Description Non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity than GYKI 52466 (Cat. No. 1454). Potentiates the anticonvulsive activity of antiepileptic drugs in animal models of seizures. Orally active.
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Product References

LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the - LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the

Czuczwar SJ, Swiader M, Kuzniar H, Gasior M, Kleinrok Z. Eur J Pharmacol. 1998 Oct 23;359(2-3):103-9.

The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant - The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant

Borowicz KK, Kleinrok Z, Czuczwar SJ. Naunyn Schmiedebergs Arch Pharmacol. 2000 Jun;361(6):629-35.

Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after - Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after

Belayev L, Alonso OF, Liu Y, Chappell AS, Zhao W, Ginsberg MD, Busto R. J Neurotrauma. 2001 Oct;18(10):1031-8.