Taltirelin

• Supplier: Tocris Bioscience
• Catalog: 4352
• Prices: $105.00, $225.00
• Sizes: 1 mg, 10 mg
• Cas Number: 103300-74-9
• Chemical Name: N-[[(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-L-prolinamide
• Formula: C17H23N7O5
• Molecular Weight: 405.41
• Purity: >96 %
• Description: Synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective.

Product References

Synthesis and central nervous system actions of thyrotropin-releasing hormone - Synthesis and central nervous system actions of thyrotropin-releasing hormone

Suzuki M, Sugano H, Matsumoto K, Yamamura M, Ishida R. J Med Chem. 1990 Aug;33(8):2130-7.

Neuroprotective effect and brain receptor binding of taltirelin, a novel - Neuroprotective effect and brain receptor binding of taltirelin, a novel

Urayama A, Yamada S, Kimura R, Zhang J, Watanabe Y. Life Sci. 2002 Dec 20;72(4-5):601-7.

The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive - The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive

Tanabe M, Tokuda Y, Takasu K, Ono K, Honda M, Ono H. Br J Pharmacol. 2007 Feb;150(4):403-14. Epub 2007 Jan 15.