| Name | TAME hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2672 |
| Prices | $49.00 |
| Sizes | 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1784-03-8 |
| Chemical Name | N2-[(4-Methylphenyl)sulfonyl]-L-argininemethylesterhydrochloride |
| Formula | C14H22N4O4S.HCl |
| Molecular Weight | 378.87 |
| Purity | >99 % |
| Description | Competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC 50 = 12 μ M) and blocks cyclin degradation in interphase extract. |
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Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh DC, Hathaway N, Dimova N, Cuny GD, King RW. Cancer Cell. 2010 Oct 19;18(4):382-95.
Zeng X, King RW. Nat Chem Biol. 2012 Feb 26;8(4):383-92.