Tandospirone hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3050
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 99095-10-0
• Chemical Name: (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dionehydrochloride
• Formula: C21H29N5O2.HCl
• Molecular Weight: 419.95
• Purity: >98 %
• Description: 5-HT 1A receptor partial agonist (K i = 27 nM) that displays selectivity over 5-HT 2 , 5-HT 1C , α 1 , α 2 , D 1 and D 2 receptors (K i values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT 1B , β -adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.

Product References

Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor - Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor

Hamik A, Oksenberg D, Fischette C, Peroutka SJ. Biol Psychiatry. 1990 Jul 15;28(2):99-109.

Effects of tandospirone in three behavioral tests for anxiolytics. - Effects of tandospirone in three behavioral tests for anxiolytics.

Pollard GT, Nanry KP, Howard JL. Eur J Pharmacol. 1992 Oct 20;221(2-3):297-305.

Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via - Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via

Matsubara K, Shimizu K, Suno M, Ogawa K, Awaya T, Yamada T, Noda T, Satomi M, Ohtaki K, Chiba K, Tasaki Y, Shiono H. Brain Res. 2006 Sep 27;1112(1):126-33. Epub 2006 Aug 1.