Tariquidar dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4426
• Prices: $179.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Chemical Name: N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarbxamidedihydrochloride
• Formula: C38H38N4O6.2HCl
• Molecular Weight: 719.66
• Purity: >98 %
• Description: Potent P-glycoprotein (P-gp) inhibitor (IC 50 = 5.1 nM). Reverses drug resistance in multiple MDR cell lines. Acts as a substrate for breast cancer resistance protein (BCRP) at low concentrations and acts as an inhibitor of BCRP when used at >100 nM concentration. Potentiates the cytotoxic effects of doxorubicin (Cat. No. 2252) and mitoxantrone (Cat. No. 4250) in vitro .

Product References

TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits - TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits

Muranaka Y, Yamasaki Y, Nozawa Y, Terakawa H, Tanahashi Y, Oda N, Satoh A, Asao T, Miyake H, Matsuura N. J Pharmacol Exp Ther. 1998 Jun;285(3):1280-6.

TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth - TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth

Sasaki E, Nozawa Y, Miyoshi K, Kanda A, Yamasaki Y, Miyake H, Matsuura N. Jpn J Pharmacol. 2000 Nov;84(3):252-8.