Tautomycetin

• Supplier: Tocris Bioscience
• Catalog: 0209
• Prices: $299.00
• Sizes: 50 µg
• Function Type: Inhibitor
• Cas Number: 119757-73-2
• Chemical Name: (1R,2S,3R,6S,7S,10S,12R,15E,βR,3R)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoicacidester
• Formula: C33H50O10
• Molecular Weight: 606.75
• Purity: >95 %
• Description: Selective inhibitor of protein phosphatase (PP)1 (IC 50 values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo . Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells.

Product References

Tautomycetin is a novel and specific inhibitor of serine/threonine protein - Tautomycetin is a novel and specific inhibitor of serine/threonine protein

Mitsuhashi S, Matsuura N, Ubukata M, Oikawa H, Shima H, Kikuchi K. Biochem Biophys Res Commun. 2001 Sep 21;287(2):328-31.

Immunosuppressive effects of tautomycetin in vivo and in vitro via T - Immunosuppressive effects of tautomycetin in vivo and in vitro via T

Shim JH, Lee HK, Chang EJ, Chae WJ, Han JH, Han DJ, Morio T, Yang JJ, Bothwell A, Lee SK. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10617-22. Epub 2002 Jul 29.

Effects of tautomycetin on proliferation and fibronectin secretion in vascular - Effects of tautomycetin on proliferation and fibronectin secretion in vascular

Kim JH, Lee TY, Park J, Ha H, Kang SW, Kim YS. Transplant Proc. 2005 May;37(4):1959-61.