Taxol

• Supplier: Tocris Bioscience
• Catalog: 2305
• Prices: $129.00, $489.00
• Sizes: 10 mg, 50 mg
• Cas Number: 33069-62-4
• Chemical Name: [2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylesterbenzenepropanoicacid
• Formula: C47H51NO14
• Molecular Weight: 853.92
• Purity: >99 %
• Description: Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.

Product References

Taxol: a unique antineoplastic agent with significant activity in advanced - Taxol: a unique antineoplastic agent with significant activity in advanced

McGuire WP, Rowinsky EK, Rosenshein NB, Grumbine FC, Ettinger DS, Armstrong DK, Donehower RC. Ann Intern Med. 1989 Aug 15;111(4):273-9.

Taxol: a novel investigational antimicrotubule agent. - Taxol: a novel investigational antimicrotubule agent.

Rowinsky EK, Cazenave LA, Donehower RC. J Natl Cancer Inst. 1990 Aug 1;82(15):1247-59.

Characterization of the Taxol binding site on the microtubule. Identification of - Characterization of the Taxol binding site on the microtubule. Identification of

Rao S, He L, Chakravarty S, Ojima I, Orr GA, Horwitz SB. J Biol Chem. 1999 Dec 31;274(53):37990-4.

Taxol induces caspase-10-dependent apoptosis. - Taxol induces caspase-10-dependent apoptosis.

Park SJ, Wu CH, Gordon JD, Zhong X, Emami A, Safa AR. J Biol Chem. 2004 Dec 3;279(49):51057-67. Epub 2004 Sep 27.