Tazarotene

Name Tazarotene
Supplier Tocris Bioscience
Catalog 1097
Prices $169.00, $705.00
Sizes 10 mg, 50 mg
Cas Number 118292-40-3
Chemical Name 6-[2-(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylicacidethylester
Formula C21H21NO2S
Molecular Weight 351.46
Purity >99 %
Description Receptor-selective acetylenic retinoid; binds at retinoid acid receptors (RAR) - β and - γ . Topically used for the treatment of skin disorders, particularly psoriasis and acne. Implicated in the treatment of basal cell carcinomas; induces upregulation of Bax in vivo . Exhibits antiproliferative and proapoptotic activity. Upregulates TIGs (Tazarotene-induced genes), including the cell adhesion molecule TIG1 and the tumor-suppressor TIG3.
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Product References

Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in - Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in

Higuchi E, Chandraratna RA, Hong WK, Lotan R. Oncogene. 2003 Jul 24;22(30):4627-35.

Evidence of increased apoptosis and reduced proliferation in basal cell - Evidence of increased apoptosis and reduced proliferation in basal cell

Orlandi A, Bianchi L, Costanzo A, Campione E, Giusto Spagnoli L, Chimenti S. J Invest Dermatol. 2004 Apr;122(4):1037-41.

Expression and mutation analysis of TIG1 (tazarotene-induced gene 1) in human - Expression and mutation analysis of TIG1 (tazarotene-induced gene 1) in human

Son MS, Kang MJ, Park HC, Chi SG, Kim YH. Oncol Res. 2009;17(11-12):571-80.