TBB

• Supplier: Tocris Bioscience
• Catalog: 2905
• Prices: $89.00, $345.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 17374-26-4
• Chemical Name: 4,5,6,7-Tetrabromobenzotriazole
• Formula: C6HBr4N3
• Molecular Weight: 434.71
• Purity: >99 %
• Description: A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC 50 = 0.9 and 1.6 μ M for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.

Product References

Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of - Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of

Sarno S, Reddy H, Meggio F, Ruzzene M, Davies SP, Donella-Deana A, Shugar D, Pinna LA. FEBS Lett. 2001 May 4;496(1):44-8.

Optimization of protein kinase CK2 inhibitors derived from - Optimization of protein kinase CK2 inhibitors derived from

Pagano MA, Andrzejewska M, Ruzzene M, Sarno S, Cesaro L, Bain J, Elliott M, Meggio F, Kazimierczuk Z, Pinna LA. J Med Chem. 2004 Dec 2;47(25):6239-47.

Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective - Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective

Zien P, Duncan JS, Skierski J, Bretner M, Litchfield DW, Shugar D. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):271-80. Epub 2005 Sep 15.