TC 14012

Name	TC 14012
Supplier	Tocris Bioscience
Catalog	2669
Prices	$225.00
Sizes	1 mg
Function Type	Antagonist
Cas Number	368874-34-4
Formula	C90H140N34O19S2
Molecular Weight	2066.43
Description	CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC 50 = 350 nM for CXCR7).
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Product References

Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved - Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved

Tamamura H, Hiramatsu K, Kusano aS, Terakubo S, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N. Org Biomol Chem. 2003 Nov 7;1(21):3656-62.

Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the - Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the

Burger M, Hartmann T, Krome M, Rawluk J, Tamamura H, Fujii N, Kipps TJ, Burger JA. Blood. 2005 Sep 1;106(5):1824-30. Epub 2005 May 19.

The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: - The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7:

Gravel S, Malouf C, Boulais PE, Berchiche YA, Oishi S, Fujii N, Leduc R, Sinnett D, Heveker N. J Biol Chem. 2010 Dec 3;285(49):37939-43.