TC 2559 difumarate

Name TC 2559 difumarate
Supplier Tocris Bioscience
Catalog 2518
Prices $189.00, $765.00
Sizes 10 mg, 50 mg
Function Type Agonist
Cas Number 212332-35-9
Chemical Name 4-(5-ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-aminedifumarate
Formula C12H18N2O.2C4H4O4
Molecular Weight 438.43
Purity >98 %
Description Subtype-selective partial agonist for α 4 β 2 nicotinic acetylcholine receptors (EC 50 values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μ M for α 4 β 2, α 4 β 4, α 2 β 4, α 3 β 4, α 3 β 2 and α 7 receptor subtypes respectively). Displays selectivity for ( α 4) 2 ( β 2) 3 receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Attenuates scopolamine-induced cognitive deficits in a step-through passive avoidance task.
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Product References

TC-2559: a novel orally active ligand selective at neuronal acetylcholine - TC-2559: a novel orally active ligand selective at neuronal acetylcholine

Bencherif M, Bane AJ, Miller CH, Dull GM, Gatto GJ. Eur J Pharmacol. 2000 Dec 1;409(1):45-55.

The nicotinic alpha 4 beta 2 receptor selective agonist, TC-2559, increases - The nicotinic alpha 4 beta 2 receptor selective agonist, TC-2559, increases

Chen Y, Sharples TJ, Phillips KG, Benedetti G, Broad LM, Zwart R, Sher E. Neuropharmacology. 2003 Sep;45(3):334-44.

5-I A-85380 and TC-2559 differentially activate heterologously expressed - 5-I A-85380 and TC-2559 differentially activate heterologously expressed

Zwart R, Broad LM, Xi Q, Lee M, Moroni M, Bermudez I, Sher E. Eur J Pharmacol. 2006 Jun 6;539(1-2):10-7. Epub 2006 Apr 5.