| Name | TC ASK 10 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5412 |
| Prices | $225.00, $925.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1005775-56-3 |
| Chemical Name | 4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamidedihydrochloride |
| Formula | C21H21N5O.2HCl |
| Molecular Weight | 432.35 |
| Purity | >98 % |
| Description | Potent ASK1 inhibitor (IC 50 = 14 nM); displays selectivity for ASK1 over other kinases including ASK2 (IC 50 = 0.51 μ M), MEKK1, TAK1, IKK β , ERK1, JNK1, p38 α , GSK-3 β , PKC θ and B-raf (IC 50 values are > 10 μ M). Blocks downstream JNK1/p38 phosphorylation in cells. Orally bioavailable. |
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