TC Mps1 12

Name	TC Mps1 12
Supplier	Tocris Bioscience
Catalog	4708
Prices	$199.00, $825.00
Sizes	10 mg, 50 mg
Function Type	Inhibitor
Cas Number	1206170-62-8
Chemical Name	4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
Formula	C17H20N6O
Molecular Weight	324.38
Purity	>99 %
Description	Potent and selective monopolar spindle 1 (Mps1) inhibitor (IC 50 = 6.4 nM). Selective for Mps1 over a panel of 95 kinases including JNK. Inhibits A549 lung carcinoma cell proliferation and attenuates A549 cell xenograft growth in mice. Orally active.
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Product References

Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an - Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an

Kusakabe K, Ide N, Daigo Y, Itoh T, Higashino K, Okano Y, Tadano G, Tachibana Y, Sato Y, Inoue M, Wada T, Iguchi M, Kanazawa T, Ishioka Y, Dohi K, Tagashira S, Kido Y, Sakamoto S, Yasuo K, Maeda M, Yamamoto T, Higaki M, Endoh T, Ueda K, Shiota T, Murai H, Nakamura Y. ACS Med Chem Lett. 2012 Jun 6;3(7):560-4.