TCB-2

• Supplier: Tocris Bioscience
• Catalog: 4066
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 912342-28-0
• Chemical Name: (4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylaminehydrobromide
• Formula: C11H14BrNO2.HBr
• Molecular Weight: 353.05
• Purity: >99 %
• Description: High affinity 5-HT 2A receptor agonist (K i values are 0.73 and 0.75 nM for rat and human receptors respectively). Potently stimulates IP 3 accumulation in NIH3T3 cells stably expressing rat 5-HT 2A receptors (EC 50 = 36 nM). Induces head twitches and hypothermia in mice following i.p. adminitration.

Product References

1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic - 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic

McLean TH, Parrish JC, Braden MR, Marona-Lewicka D, Gallardo-Godoy A, Nichols DE. J Med Chem. 2006 Sep 21;49(19):5794-803.

The serotonin 5-HT(2A) receptor agonist TCB-2: a behavioral and - The serotonin 5-HT(2A) receptor agonist TCB-2: a behavioral and

Fox MA, French HT, LaPorte JL, Blackler AR, Murphy DL. Psychopharmacology (Berl). 2010 Sep;212(1):13-23.

Expression and function of serotonin 2A and 2B receptors in the mammalian - Expression and function of serotonin 2A and 2B receptors in the mammalian

Niebert M, Vogelgesang S, Koch UR, Bischoff AM, Kron M, Bock N, Manzke T. PLoS One. 2011;6(7):e21395.