TC-E 5007

• Supplier: Tocris Bioscience
• Catalog: 4898
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Chemical Name: (2S,3R)-2-Amino-1-(1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-pentanonehydrochloride
• Formula: C14H20N2O.HCl
• Molecular Weight: 268.78
• Purity: >98 %
• Description: Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC 50 values are 145 and 242 nM respectively). Exhibits selectivity for DPP-8/9 over DPP-IV, DPP-2 and FAP.

Product References

Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: - Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes:

Lankas GR, Leiting B, Roy RS, Eiermann GJ, Beconi MG, Biftu T, Chan CC, Edmondson S, Feeney WP, He H, Ippolito DE, Kim D, Lyons KA, Ok HO, Patel RA, Petrov AN, Pryor KA, Qian X, Reigle L, Woods A, Wu JK, Zaller D, Zhang X, Zhu L, Weber AE, Thornberry NA. Diabetes. 2005 Oct;54(10):2988-94.

Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl - Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl

Van der Veken P, Soroka A, Brandt I, Chen YS, Maes MB, Lambeir AM, Chen X, Haemers A, Scharpe S, Augustyns K, De Meester I. J Med Chem. 2007 Nov 15;50(23):5568-70. Epub 2007 Oct 24.

Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 - Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9

Wu JJ, Tang HK, Yeh TK, Chen CM, Shy HS, Chu YR, Chien CH, Tsai TY, Huang YC, Huang YL, Huang CH, Tseng HY, Jiaang WT, Chao YS, Chen X. Biochem Pharmacol. 2009 Jul 15;78(2):203-10.