| Name | TC-E 5008 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5204 |
| Prices | $145.00, $609.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 50405-58-8 |
| Chemical Name | 1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone |
| Formula | C13H13NO2 |
| Molecular Weight | 215.25 |
| Description | Selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor (K i = 120-190 nM). Displays >60-fold selectivity for mIDH1 (found in ~75% of gliomas) over wild type IDH1. Also inhibits D -2-hydroxyglutaric acid in cells expressing mIDH1 (EC 50 = 2.4 μ M). Does not display cytotoxicity towards non-cancerous human cells. Phenotypically lethal. |
| Supplier Page | Shop |
Gustin DJ, Ma Z, Min X, Li Y, Hedberg C, Guimaraes C, Porter AC, Lindstrom M, Lester-Zeiner D, Xu G, Carlson TJ, Xiao S, Meleza C, Connors R, Wang Z, Kayser F. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2492-6.
Min X, Thibault ST, Porter AC, Gustin DJ, Carlson TJ, Xu H, Lindstrom M, Xu G, Uyeda C, Ma Z, Li Y, Kayser F, Walker NP, Wang Z. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7379-84. doi: