TC-FPR 43

• Supplier: Tocris Bioscience
• Catalog: 4355
• Prices: $179.00, $745.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 903895-98-7
• Chemical Name: N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea
• Formula: C20H21ClN4O2
• Molecular Weight: 384.86
• Purity: >98 %
• Description: Potent formyl peptide receptor 2 (FPR2) agonist (EC 50 = 44 nM). Inhibits fMLP- and IL-8-induced neutrophil migration. Suppresses inflammation in a mouse model of acute inflammation. Orally bioavailable.

Product References

Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. - Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents.

Burli RW, Xu H, Zou X, Muller K, Golden J, Frohn M, Adlam M, Plant MH, Wong M, McElvain M, Regal K, Viswanadhan VN, Tagari P, Hungate R. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3713-8. Epub 2006 May 11.

Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific - Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific

Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, D'Acquisto F, Buckingham JC, Perretti M, Flower RJ. J Immunol. 2010 Mar 1;184(5):2611-9.

Stable formyl peptide receptor agonists that activate the neutrophil - Stable formyl peptide receptor agonists that activate the neutrophil

Forsman H, Kalderen C, Nordin A, Nordling E, Jensen AJ, Dahlgren C. Biochem Pharmacol. 2011 Feb 1;81(3):402-11.