TC-H 106

• Supplier: Tocris Bioscience
• Catalog: 4353
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 937039-45-7
• Chemical Name: N1-(2-Aminophenyl)-N7-(4-methylphenyl)heptanediamide
• Formula: C20H25N3O2
• Molecular Weight: 339.43
• Purity: >99 %
• Description: Class I histone deacetylase (HDAC) inhibitor (IC 50 values are 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively). Exhibits slow, tight-binding inhibitory activity. Displays no activity against class II HDACs. Brain penetrant.

Product References

Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone - Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone

Chou CJ, Herman D, Gottesfeld JM. J Biol Chem. 2008 Dec 19;283(51):35402-9.

HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model. - HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model.

Rai M, Soragni E, Jenssen K, Burnett R, Herman D, Coppola G, Geschwind DH, Gottesfeld JM, Pandolfo M. PLoS One. 2008 Apr 9;3(4):e1958.

Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia - Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia

Xu C, Soragni E, Chou CJ, Herman D, Plasterer HL, Rusche JR, Gottesfeld JM. Chem Biol. 2009 Sep 25;16(9):980-9.