| Name | TC-I 15 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4270 |
| Prices | $225.00, $925.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 916734-43-5 |
| Chemical Name | N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine |
| Formula | C23H28N4O6S2 |
| Molecular Weight | 520.62 |
| Purity | >98 % |
| Description | Potent α 2 β 1 integrin inhibitor (IC 50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). Displays selectivity for α 2 β 1 over α v β 3 , α 5 β 1 , α 6 β 1 and α IIb β 3 at concentrations exceeding 1000 nM. Reduces collagen IV production in mesangial cells. Active in vivo ; prevents ferric chloride-induced clot formation in mice. |
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Miller MW, Basra S, Kulp DW, Billings PC, Choi S, Beavers MP, McCarty OJ, Zou Z, Kahn ML, Bennett JS, DeGrado WF. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):719-24. doi:
Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A. J Am Soc Nephrol. 2012 Jun;23(6):1027-38.