TCID

• Supplier: Tocris Bioscience
• Catalog: 5410
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 30675-13-9
• Chemical Name: 4,5,6,7-Tetrachloro-1H-Indene-1,3(2H)-dione
• Formula: C9H2Cl4O2
• Molecular Weight: 283.92
• Purity: >99 %
• Description: Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor (IC 50 = 0.6 μ M). Exhibits >100-fold selectivity for UCH-L3 over UCH-L1. Diminishes glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.

Product References

Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 - Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299

Liu Y, Lashuel HA, Choi S, Xing X, Case A, Ni J, Yeh LA, Cuny GD, Stein RL, Lansbury PT Jr. Chem Biol. 2003 Sep;10(9):837-46.

Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 - Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2

de Juan-Sanz J, Nunez E, Lopez-Corcuera B, Aragon C. PLoS One. 2013;8(3):e58863.