| Name | TC-MCH 7c |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5179 |
| Prices | $255.00 |
| Sizes | 10 mg |
| Function Type | Antagonist |
| Cas Number | 864756-35-4 |
| Chemical Name | 4-[(4-Fluorophenyl)methoxy]-1-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2(1H)-pyridinone |
| Formula | C24H25FN2O3 |
| Molecular Weight | 408.47 |
| Purity | >97 % |
| Description | Potent, selective melanin-concentrating hormone receptor 1 (MCH 1 R) antagonist (IC 50 = 5.6 nM in hMCH 1 R-expressing CHO cells). Displays selectivity for MCH 1 R over MCH 2 R (IC 50 = > 10 μ M). Decreases body weight in a mouse model of diet-induced obesity. Brain penetrant; orally active. |
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Ito M, Ishihara A, Gomori A, Egashira S, Matsushita H, Mashiko S, Ito J, Ito M, Nakase K, Haga Y, Iwaasa H, Suzuki T, Ohtake N, Moriya M, Sato N, MacNeil DJ, Takenaga N, Tokita S, Kanatani A. Eur J Pharmacol. 2009 Dec 10;624(1-3):77-83.
Haga Y, Mizutani S, Naya A, Kishino H, Iwaasa H, Ito M, Ito J, Moriya M, Sato N, Takenaga N, Ishihara A, Tokita S, Kanatani A, Ohtake N. Bioorg Med Chem. 2011 Jan 15;19(2):883-93.