TCN 201

• Supplier: Tocris Bioscience
• Catalog: 4435
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 852918-02-6
• Chemical Name: 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
• Formula: C21H17ClFN3O4S
• Molecular Weight: 461.89
• Purity: >99 %
• Description: NMDA receptor antagonist selective for NR1/NR2A over NR1/NR2B-containing receptors (pIC 50 values are 6.8 and <4.3, respectively, in human recombinant NR1/NR2A and NR1/NR2B FLIPR/Ca 2+ assays).

Product References

Identification and characterization of novel NMDA receptor antagonists selective - Identification and characterization of novel NMDA receptor antagonists selective

Bettini E, Sava A, Griffante C, Carignani C, Buson A, Capelli AM, Negri M, Andreetta F, Senar-Sancho SA, Guiral L, Cardullo F. J Pharmacol Exp Ther. 2010 Dec;335(3):636-44.

Subtype selective NMDA receptor antagonists induce recovery of synapses lost - Subtype selective NMDA receptor antagonists induce recovery of synapses lost

Shin AH, Kim HJ, Thayer SA. Br J Pharmacol. 2012 Jun;166(3):1002-17.

TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist - TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist

Edman S, McKay S, Macdonald LJ, Samadi M, Livesey MR, Hardingham GE, Wyllie DJ. Neuropharmacology. 2012 Sep;63(3):441-9.

Subunit-selective allosteric inhibition of glycine binding to NMDA receptors. - Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.

Hansen KB, Ogden KK, Traynelis SF. J Neurosci. 2012 May 2;32(18):6197-208.

Reinstatement of nicotine seeking is mediated by glutamatergic plasticity. - Reinstatement of nicotine seeking is mediated by glutamatergic plasticity.

Gipson CD, Reissner KJ, Kupchik YM, Smith AC, Stankeviciute N, Hensley-Simon ME, Kalivas PW. Proc Natl Acad Sci U S A. 2013 May 28;110(22):9124-9. doi: