| Name | TCN 237 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4370 |
| Prices | $165.00 |
| Sizes | 10 mg |
| Function Type | Antagonist |
| Cas Number | 700878-19-9 |
| Chemical Name | 2-[[4-[(2-Fluorophenyl)methyl]-1-piperidinyl]methyl]-1H-benzimidazol-6-oldihydrochloride |
| Formula | C20H22FN3O.2HCl |
| Molecular Weight | 412.33 |
| Purity | >98 % |
| Description | Highly potent NR2B-selective NMDA receptor antagonist (K i = 0.8 nM); blocks NR2B-mediated calcium influx in Ltk cells (K i = 9.7 nM). Selective for NR2B subunit over α 1 -adrenergic receptors and hERG channels (IC 50 values are 730 nM and 2900 nM respectively). Displays efficacy in the rat carrageenan-induced mechanical hyperalgesia assay. |
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