TCS 1205

• Supplier: Tocris Bioscience
• Catalog: 3942
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 355022-97-8
• Chemical Name: 5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide
• Formula: C18H15N3O4
• Molecular Weight: 337.33
• Purity: >99 %
• Description: GABA A α 2 agonist and GABA A α 1 partial agonist in vitro (K i values are 14 and 121 nM respectively). Exhibits non-sedative anxiolytic activity in vivo .

Product References

Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the - Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the

Primofiore G, Settimo FD, Taliani S, Marini AM, Novellino E, Greco G, Lavecchia A, Besnard F, Trincavelli L, Costa B, Martini C. J Med Chem. 2001 Jul 5;44(14):2286-97.

Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides - Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides

Taliani S, Cosimelli B, Da Settimo F, Marini AM, La Motta C, Simorini F, Salerno S, Novellino E, Greco G, Cosconati S, Marinelli L, Salvetti F, L'Abbate G, Trasciatti S, Montali M, Costa B, Martini C. J Med Chem. 2009 Jun 25;52(12):3723-34.