TCS 401

• Supplier: Tocris Bioscience
• Catalog: 2591
• Prices: $199.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 243966-09-8
• Chemical Name: 2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylicacidhydrochloride
• Formula: C10H10N2O5S.HCl
• Molecular Weight: 306.72
• Purity: >98 %
• Description: Selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (K i values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μ M for PTP1B, CD45 D1D2, PTP β , PTP ε D1, SHP-1, PTP α D1 and LAR D1D2 respectively).

Product References

Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and - Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and

Iversen LF, Andersen HS, Branner S, Mortensen SB, Peters GH, Norris K, Olsen OH, Jeppesen CB, Lundt BF, Ripka W, Moller KB, Moller NP. J Biol Chem. 2000 Apr 7;275(14):10300-7.

Discovery and SAR of a novel selective and orally bioavailable nonpeptide - Discovery and SAR of a novel selective and orally bioavailable nonpeptide

Andersen HS, Olsen OH, Iversen LF, Sorensen AL, Mortensen SB, Christensen MS, Branner S, Hansen TK, Lau JF, Jeppesen L, Moran EJ, Su J, Bakir F, Judge L, Shahbaz M, Collins T, Vo T, Newman MJ, Ripka WC, Moller NP. J Med Chem. 2002 Sep 26;45(20):4443-59.