TCS 46b

• Supplier: Tocris Bioscience
• Catalog: 2754
• Prices: $165.00, $685.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 302799-86-6
• Chemical Name: 1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-2H-benzimidazol-2-one
• Formula: C22H23N3O
• Molecular Weight: 345.44
• Purity: >98 %
• Description: Orally active, subtype-selective NR1A/NR2B NMDA receptor antagonist (IC 50 values are 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes respectively). Potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration.

Product References

Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and - Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and

Wright JL, Gregory TF, Kesten SR, Boxer PA, Serpa KA, Meltzer LT, Wise LD, Espitia SA, Konkoy CS, Whittemore ER, Woodward RM. J Med Chem. 2000 Sep 7;43(18):3408-19.

Synthesis, radiosynthesis and in vivo evaluation of - Synthesis, radiosynthesis and in vivo evaluation of

Roger G, Lagnel B, Besret L, Bramoulle Y, Coulon C, Ottaviani M, Kassiou M, Bottlaender M, Valette H, Dolle F. Bioorg Med Chem. 2003 Dec 1;11(24):5401-8.