TCS 5861528

• Supplier: Tocris Bioscience
• Catalog: 2782
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 332117-28-9
• Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide
• Formula: C19H23N5O3
• Molecular Weight: 369.42
• Purity: >98 %
• Description: TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC 50 values are 14.3 and 18.7 μ M respectively). Attenuates diabetic hypersensitivity in an in vivo rat model.

Product References

Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion - Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion

Wei H, Hamalainen MM, Saarnilehto M, Koivisto A, Pertovaara A. Anesthesiology. 2009 Jul;111(1):147-54.

Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in - Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in

Wei H, Chapman H, Saarnilehto M, Kuokkanen K, Koivisto A, Pertovaara A. Neuropharmacology. 2010 Mar;58(3):578-84.