| Name | TC-S 7001 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3938 |
| Prices | $195.00 |
| Sizes | 1 mg |
| Function Type | Inhibitor |
| Cas Number | 867017-68-3 |
| Chemical Name | 6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine |
| Formula | C18H13ClF2N6O |
| Molecular Weight | 402.79 |
| Purity | >98 % |
| Description | Potent and highly selective ROCK inhibitor (IC 50 values are 0.6 and 1.1 nM for ROCK1 and ROCK2, respectively). Exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. Reduces blood pressure in normotensive and hypertensive rats. Orally active. |
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Kast R, Schirok H, Figueroa-Perez S, Mittendorf J, Gnoth MJ, Apeler H, Lenz J, Franz JK, Knorr A, Hutter J, Lobell M, Zimmermann K, Munter K, Augstein KH, Ehmke H, Stasch JP. Br J Pharmacol. 2007 Dec;152(7):1070-80. Epub 2007 Oct 15.
Dahal BK, Kosanovic D, Pamarthi PK, Sydykov A, Lai YJ, Kast R, Schirok H, Stasch JP, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Schermuly RT. Eur Respir J. 2010 Oct;36(4):808-18.