TC-S 7004

Name	TC-S 7004
Supplier	Tocris Bioscience
Catalog	3567
Prices	$195.00, $805.00
Sizes	10 mg, 50 mg
Function Type	Inhibitor
Cas Number	1386979-55-0
Chemical Name	N-[2-Chloro-5-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]-7,8-dihydro-2-methoxy-7-oxopyrido[2,3-d]pyrimidine-6-carboxamide
Formula	C23H17Cl2N5O4
Molecular Weight	498.32
Purity	>98 %
Description	Potent and selective DYRK1A/B inhibitor (IC 50 values are 22 and 68 nM respectively). Selective for DYRK1A/B over a panel of other kinases. Reduces accumulation of quiescent Panc1 pancreatic cancer cells in G 0 under serum free conditions. Also induces DNA damage and apoptosis in quiescent Panc1 cells.
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Product References

Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. - Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells.

Ewton DZ, Hu J, Vilenchik M, Deng X, Luk KC, Polonskaia A, Hoffman AF, Zipf K, Boylan JF, Friedman EA. Mol Cancer Ther. 2011 Nov;10(11):2104-14.

Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of - Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of

Anderson K, Chen Y, Chen Z, Dominique R, Glenn K, He Y, Janson C, Luk KC, Lukacs C, Polonskaia A, Qiao Q, Railkar A, Rossman P, Sun H, Xiang Q, Vilenchik M, Wovkulich P, Zhang X. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5.