TC-S 7006

• Supplier: Tocris Bioscience
• Catalog: 4459
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 871307-18-5
• Chemical Name: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
• Formula: C21H14ClFN6
• Molecular Weight: 404.83
• Purity: >99 %
• Description: Potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC 50 = 50 nM). Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. Inhibits LPS-induced TNF- α secretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferation in vitro . Also reduces cytolytic activity of human CD8 + cytotoxic T lymphocytes. Cell permeable.

Product References

Inhibition of Tpl2 kinase and TNF-alpha production with - Inhibition of Tpl2 kinase and TNF-alpha production with

Gavrin LK, Green N, Hu Y, Janz K, Kaila N, Li HQ, Tam SY, Thomason JR, Gopalsamy A, Ciszewski G, Cuozzo JW, Hall JP, Hsu S, Telliez JB, Lin LL. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92. Epub 2005 Sep 13.

Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and - Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and

Wang X, Gocek E, Novik V, Harrison JS, Danilenko M, Studzinski GP. Cell Cycle. 2010 Nov 15;9(22):4542-51. Epub 2010 Nov 15.

Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte - Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte

Chowdhury FZ, Estrada LD, Murray S, Forman J, Farrar JD. PLoS One. 2014 Mar 18;9(3):e92187.